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We conclude that peripheral neuropathy and isolated sicca complex form a distinctive syndrome in which neuropathy is the presenting feature and sicca is easily overlooked;sensory polyneuropathy and polyganglionopathy predominate;serology is confirmatory but very insensitive;and extraglandular disease,including vasculitis,is uncommon compared with typical Sjogren's syndrome.Tests of ocular or salivary disease,including vasculitis,is uncommon compared with typical Sjogren's syndrome.Tests of ocular or salivary involvement are needed for diagnosis,and demonstration of inflammation in biopsied nerve is supportive.Improved definition of this disorder should permit further studies of natural history and efficacy of immunotherapy. |
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